Erectile Dysfunction Pills: What Works, What Doesn't, and How to Choose

When you're dealing with erectile dysfunction pills, medications designed to help men achieve and maintain an erection by improving blood flow to the penis. Also known as PDE5 inhibitors, they're one of the most common treatments for ED—but they’re not all the same. Some work faster, some last longer, and some come with side effects that can catch you off guard if you don’t know what to expect.

Not every man reacts the same way to these drugs. Sildenafil, the active ingredient in Viagra, is the most well-known ED pill. It usually kicks in within 30 to 60 minutes and lasts about 4 to 5 hours. But if you’ve tried it and it didn’t work well, or you got headaches or flushing, you’re not alone. Avanafil, a newer option found in Stendra, works just as well but often starts faster—sometimes in as little as 15 minutes—and causes fewer side effects. Then there’s Dapoxetine, a pill designed for men who struggle with both erectile dysfunction and premature ejaculation. It’s not just an ED pill—it’s a dual-purpose tool that helps you last longer while still getting an erection.

What most guides leave out is that your choice isn’t just about the drug—it’s about your body, your routine, and your goals. If you’re spontaneous, you want something fast. If you’re planning ahead, you might prefer a longer-lasting option. If you’re on other meds, like nitrates for heart issues, some ED pills are off-limits. And if you’re mixing ED pills with alcohol or high-fat meals, that can delay or weaken the effect. The best pill isn’t the most popular one—it’s the one that fits your life without fighting it.

Below, you’ll find real comparisons between these pills and others—what they actually do, how they stack up against each other, and which ones come with hidden risks. No fluff. No marketing. Just what you need to know before you take the next pill.